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![Figure 3.](/view/journals/anpr/61/4/inline-i0003-3006-61-4-150-f03.png)
The effect of adrenaline at each concentration on mean blood pressure (MBP) (a) and pulse rate (PR) (b) in chlorpromazine-pretreated rats (saline: n = 4; 1 μg/kg: n = 6; 10 μg/kg: n = 4; 100 μg/kg: n = 6). Adrenaline at each concentration induced hypotension and tachycardia, and 100 μg/kg adrenaline induced significant hemodynamic changes. P values are for the comparisons at each concentration of adrenaline by using 1-way analysis of variance with Dunnett's post hoc test (vs saline). Data represent means ± SD.
![Figure 1.](/view/journals/anpr/61/4/inline-i0003-3006-61-4-150-f01.png)
The time course of percentage change of mean blood pressure (MBP) (a) and pulse rate (PR) (b) after the injection of saline or 100 μg/kg adrenaline (AD) in chlorpromazine (Ch)-pretreated rats and saline-pretreated rats (Ch + saline: n = 4; Ch + AD: n = 6; saline + AD: n = 4). P values are for between-agent comparisons (vs the value for Ch + saline) at specified time intervals by using 2-way analysis of variance with Bonferroni's post hoc test. Data represent mean ± SD.
![Figure 2.](/view/journals/anpr/61/4/inline-i0003-3006-61-4-150-f02.png)
The blockade effect of propranolol (Pro) on hemodynamic changes by drug interaction between adrenaline (AD) and chlorpromazine (Ch) on mean blood pressure (MBP) (a) and pulse rate (PR) (b) (Ch + saline: n = 4; Ch + Pro + AD: n = 3). AD induced modest hypertension, but did not significantly influence pulse rate change in Pro + Ch–pretreated rats. P values are for between-agent comparisons (vs the value for Ch + saline) at specified time intervals by using 2-way analysis of variance with Bonferroni's post hoc test. Data represent means ± SD.
![<bold>Figure 4</bold>](/view/journals/anpr/61/3/inline-i0003-3006-61-3-120-f04.png)
Regular users of antipsychotics who received lidocaine hydrochloride solution containing adrenaline during dental treatment
![<bold>Figure 3</bold>](/view/journals/anpr/61/3/inline-i0003-3006-61-3-120-f03.png)
Hospitals in which lidocaine hydrochloride solution containing adrenaline was administered to regular users of antipsychotics during dental treatment
![<bold>Figure 5</bold>](/view/journals/anpr/61/3/inline-i0003-3006-61-3-120-f05.png)
Adverse effects after the administration of lidocaine hydrochloride solution containing adrenaline to regular users of antipsychotics
![Figure 5.](/view/journals/anpr/58/3/inline-i0003-3006-58-3-140-f05.png)
Concentrations of radioactivity derived from 14C-lidocaine in the serum.
After 20 µl of 2% 14C-lidocaine with (•) and without (○) 10 µg/ml adrenaline was injected into the right palatal mucosa proximal to the first molar, the radioactive concentration (dpm/ml) in the serum was measured with a liquid scintillation counter. The serum lidocaine concentration after the injection of lidocaine with adrenaline was significantly lower from 2 to 50 minutes and higher after 60 minutes than that when injected alone.
Data are mean ± SD (n = 7), * p<0.05 plain lidocaine vs lidocaine with adrenaline.
![Fig. 3](/view/journals/anpr/56/4/inline-i0003-3006-56-4-147-f03.gif)
Change of RBF in each group. Data are expressed as mean ± SD (Adrenaline or DEX in Lidocaine)
* : p<0.01 L vs LA
⋇: p<0.01 L vs LD
† : p<0.01 vs Baseline in LA