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![Figure 1](/view/journals/anpr/55/2/inline-i0003-3006-55-2-49-f01.gif)
Summary of thrombogenesis and thrombolysis. A thrombus consists of 2 principal components: an aggregate of platelets and a fibrin mesh. Platelet activity consists of adherence to vessel walls (adhesion) and to one another (aggregation). The fibrin mesh is synthesized during a complex cascade of enzymatic reactions leading to the formation of fibrin strands (coagulation). The body also has a natural thrombolytic system, essentially comprised of plasmin, an enzyme that cleaves fibrin strands. Antithrombotic drugs are classified according to action on each of these processes: antiplatelet drugs, anticoagulants, and thrombolytics (fibrinolytics).
![<bold>Figure 1.</bold>](/view/journals/anpr/60/2/inline-i0003-3006-60-2-72-f01.png)
Thrombogenesis. A thrombus consists of 2 principal components: an aggregate of platelets and a fibrin mesh. Platelet activity consists of adherence to vessel walls (adhesion) and to one another (aggregation). The fibrin mesh is synthesized during a complex cascade of enzymatic reactions leading to the formation fibrin strands (coagulation). The body also has a natural thrombolytic system, essentially comprised of plasmin, an enzyme that cleaves fibrin strands. Antithrombotic drugs are classified according to action on each of these processes: antiplatelet drugs, anticoagulants, and thrombolytics (fibrinolytics).
![Figure 1.](/view/journals/anpr/69/3/inline-i1878-7177-69-3-40-f01.png)
Classic coagulation cascade model featuring the extrinsic, intrinsic, and common coagulation pathways.
![Figure 2.](/view/journals/anpr/69/3/inline-i1878-7177-69-3-40-f02.png)
Contemporary coagulation model demonstrating the 3 phases: activation (A-C), amplification (D-F), and clot propagation (G). 3