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Anesthesia Management of a Patient With Familial Cold Autoinflammatory Syndrome: A Case Report
Ruri Teshima DDS,
 Akiko Nishimura DDS, PhD,
 Akira Hara DDS,
 Yuhei Ubukata DDS,
 Sayaka Chizuwa DDS,
 Mone Wakatsuki DDS, and
 Takehiko Iijima DDS, PhD
Article Category: Brief Report
Volume/Issue: Volume 69: Issue 3
Online Publication Date: Oct 06, 2022
DOI: 10.2344/anpr-69-02-04
Page Range: 38 – 39

Cryopyrin-associated periodic syndrome (CAPS) is a rare autosomal dominant inherited disorder comprised of 3 phenotypes and characterized by repetitive systemic inflammation. Familial cold autoinflammatory syndrome (FCAS) is 1 phenotype of CAPS with symptoms that include fever, fatigue, rashes, headaches, and arthralgia. 1 FCAS/CAPS symptoms are triggered by cold stimulation and continue for a few hours or several days. In the case presented below, we prewarmed the patient before anesthesia induction and monitored her core and peripheral

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Figure 4. ; % change of CAPs for 47.02 μM YOH (n = 6) The CAPs amplitude was inhibited by 50% of the EC50 YOH, but it did not recover to the control values after the washout.
<bold>Figure 4.</bold>
Figure 4.

% change of CAPs for 47.02 μM YOH (n = 6)

The CAPs amplitude was inhibited by 50% of the EC50 YOH, but it did not recover to the control values after the washout.

Figure 5. ; % change of CAPs for 5.98 μM DEX + 23.51 μM YOH (n = 22) The mixture solution containing 1/2 EC50 DEX and 1/2 EC50 YOH reduced the CAPs amplitude to close to 50% of the control CAPs amplitude. As a result, the relationships between DEX and YOH show that it represents an additive effect.
<bold>Figure 5.</bold>
Figure 5.

% change of CAPs for 5.98 μM DEX + 23.51 μM YOH (n = 22)

The mixture solution containing 1/2 EC50 DEX and 1/2 EC50 YOH reduced the CAPs amplitude to close to 50% of the control CAPs amplitude. As a result, the relationships between DEX and YOH show that it represents an additive effect.

Figure 6. ; Effect on CAPs of IDA (n = 6) This graph shows an effect of different concentrations of IDA on the amplitude of CAPs. Reductions in the amplitude of the rat sciatic nerve by 3 different concentrations of IDA, measured 5 minutes after its application. The concentrations of IDA were 16 μM, 80 μM and 160 μM. The amplitude of the CAPs was unchanged by the administration of the IDA.
<bold>Figure 6.</bold>
Figure 6.

Effect on CAPs of IDA (n = 6)

This graph shows an effect of different concentrations of IDA on the amplitude of CAPs. Reductions in the amplitude of the rat sciatic nerve by 3 different concentrations of IDA, measured 5 minutes after its application. The concentrations of IDA were 16 μM, 80 μM and 160 μM. The amplitude of the CAPs was unchanged by the administration of the IDA.

Figure 2. ; Dose response curve of DEX (n =16) This graph shows a dose dependent decrease CAPs amplitude for DEX. DEX EC50 was 11.96 μM.
<bold>Figure 2.</bold>
Figure 2.

Dose response curve of DEX (n =16)

This graph shows a dose dependent decrease CAPs amplitude for DEX.

DEX EC50 was 11.96 μM.

Figure 7. ; % change of CAPs for 11.96 μM DEX + 80 μM IDA (n = 13), 11.96 μM DEX + Modified Liley solution (n = 8) These mixture solutions were composed of 11.96 μM DEX + 80 μM IDA and 11.96 μM DEX + Modified Liley solution, and these solutions were made by mixing equal volumes. The CAPs amplitude was indicated as the same value between groups.
<bold>Figure 7.</bold>
Figure 7.

% change of CAPs for 11.96 μM DEX + 80 μM IDA (n = 13), 11.96 μM DEX + Modified Liley solution (n = 8)

These mixture solutions were composed of 11.96 μM DEX + 80 μM IDA and 11.96 μM DEX + Modified Liley solution, and these solutions were made by mixing equal volumes.

The CAPs amplitude was indicated as the same value between groups.

JDSA Journal Abstracts
Article Category: Other
Volume/Issue: Volume 60: Issue 2
Online Publication Date: Jan 01, 2013
DOI: 10.2344/0003-3006-60.2.82
Page Range: 82 – 88

Dexmedetomidine Inhibit Compound Action Potentials Mediated through Alpha-2 Adrenalin Receptors J Jpn Dent Soc Anesthesiol 2012;40:167–172. It has been recently reported that dexmedetomidine (DEX), a selective alpha-2 adrenalin receptor agonist, prolongs the local anesthetic effects of lidocaine. Moreover, it has been reported that it controls the compound action potential (CAPs) amplitude of a rat sciatic nerve even when DEX acts alone. However, whether DEX-induced CAPs control is mediated through alpha-2 adrenalin receptors remains

The Cost of Learning From Our Mistakes
Joel M. Weaver DDS, PhD
Article Category: Research Article
Volume/Issue: Volume 58: Issue 2
Online Publication Date: Jan 01, 2011
DOI: 10.2344/0003-3006-58.2.55
Page Range: 55 – 56

remifentanil syringe, thinking that it is fentanyl, the resulting bolus of remifentanil will immediately cause chest wall rigidity, precipitating a sedation/anesthetic crisis. We also must never assume that the color of the plastic cap on a vial identifies what is in the vial, even though previous shipments of generic dexamethasone, for example, have always had pink caps. The truth is that many different drug vials have pink caps. There are no standard colors for drugs because there are many more drugs than there are colors. Professionals must recognize that we are creatures

Have Our Sterility Practices Kept Up With the Tremendous Advances in Sedation and Surgical Techniques?
Steven Ganzberg DMD, MS
Article Category: Editorial
Volume/Issue: Volume 64: Issue 4
Online Publication Date: Jan 01, 2017
DOI: 10.2344/ampr-64-04-13
Page Range: 201 – 202

stopcock, has been recognized for some time as a significant source of contamination. If used, the stopcock and cap should be decontaminated before and after use and capped when not in use. Further, the recommendations include aseptic technique when drawing up all medications, ie, clean work area, gloved hands, decontamination of rubber stopper, and, of course, a clean syringe and needle whenever entering a vial or ampule. The use of a surgical mask is recommended when drawing up medications to prevent droplet transmission from oropharyngeal flora. The recommendations