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Oral Sedation Postdischarge Adverse Events in Pediatric Dental Patients
Annie HuangDMD and
Thomas TanbonliongDDS
Article Category: Research Article
Volume/Issue: Volume 62: Issue 3
Online Publication Date: Jan 01, 2015
DOI: 10.2344/0003-3006-62.3.91
Page Range: 91 – 99

combinations of a narcotic (eg, morphine or meperidine), a sedative-hypnotic (eg, chloral hydrate), a benzodiazepine (eg, midazolam or diazepam), and/or an antihistamine (eg, hydroxyzine HCl) ( Figure 1 ) at the following dosages: 0.66 mg/kg for morphine, 2 mg /kg for meperidine, 0.5–0.7 mg/kg for midazolam, 0.5–.7 mg/kg for diazepam, and 2 mg/kg for hydroxyzine HCl. Figure 1. Distribution of oral sedation regimens. Figure 1. Distribution of oral sedation regimens. Following the

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Figure 3; Premedication in Group 1 and Group 2. a: Percentages of cases with and without premedication in both groups. b: Percentages of cases in oral midazolam, diazepam, or nothing used as premedication in both groups.
Figure 3
Figure 3

Premedication in Group 1 and Group 2.

a: Percentages of cases with and without premedication in both groups.

b: Percentages of cases in oral midazolam, diazepam, or nothing used as premedication in both groups.

Figure 3.; Premedication in Group 1 and Group 2. a: Percentages of cases with and without premedication in both groups. b: Percentages of cases in oral midazolam, diazepam, or nothing used as premedication in both groups.
Figure 3.
Figure 3.

Premedication in Group 1 and Group 2.

a: Percentages of cases with and without premedication in both groups.

b: Percentages of cases in oral midazolam, diazepam, or nothing used as premedication in both groups.

Figure 8.; Representative context-sensitive half-times. The following graph compares the time required for serum concentrations to decline by 50% upon discontinuation of varied durations of continuous infusions. With the exception of remifentanil, the context-sensitive half-times increase following greater durations of infusion. Continuous infusions of diazepam and vfentanyl result in an unacceptable time for recovery. Data are adapted from Hughes et al12 and Egan et al.13
Daniel E. Becker
Figure 8.
Figure 8.

Representative context-sensitive half-times. The following graph compares the time required for serum concentrations to decline by 50% upon discontinuation of varied durations of continuous infusions. With the exception of remifentanil, the context-sensitive half-times increase following greater durations of infusion. Continuous infusions of diazepam and vfentanyl result in an unacceptable time for recovery. Data are adapted from Hughes et al12 and Egan et al.13

Figure 1.; Distribution of oral sedation regimens.
Annie Huang and
Thomas Tanbonliong
Figure 1.
Figure 1.

Distribution of oral sedation regimens.

Figure 2.; Frequency of time to return to normal behavior and routine.
Annie Huang and
Thomas Tanbonliong
Figure 2.
Figure 2.

Frequency of time to return to normal behavior and routine.

Figure 3.; Comparison of sedation levels versus various presedation factors and behaviors.
Annie Huang and
Thomas Tanbonliong
Figure 3.
Figure 3.

Comparison of sedation levels versus various presedation factors and behaviors.

Figure 4.; Comparison of responsiveness to treatment versus presedation factors and behaviors.
Annie Huang and
Thomas Tanbonliong
Figure 4.
Figure 4.

Comparison of responsiveness to treatment versus presedation factors and behaviors.

Figure 5.; Comparison of sedation efficacy versus presedation factors and behaviors.
Annie Huang and
Thomas Tanbonliong
Figure 5.
Figure 5.

Comparison of sedation efficacy versus presedation factors and behaviors.

New Drugs on the Horizon May Improve the Quality and Safety of Anesthesia
Joel M. WeaverDDS, PhD
Article Category: Research Article
Volume/Issue: Volume 55: Issue 2
Online Publication Date: Jan 01, 2008
DOI: 10.2344/0003-3006(2008)55[27:NDOTHM]2.0.CO;2
Page Range: 27 – 28

practice of general dentistry by a newly-approved intravenous drug called diazepam (Valium). In my senior year, I had the additional opportunity of being able to use this drug with both of these instructors for some of my clinic patients and was able to see firsthand what a marvelous improvement it was over the standard intravenous sedatives that I had used the previous year. Diazepam was a revolutionary advancement in intravenous sedation. It was not just a pharmacological clone of the other sedatives, but represented a whole new class of drug with some major advantages