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A Comparison of Fospropofol to Midazolam for Moderate Sedation During Outpatient Dental Procedures
Philip YenDDS, MS,
Simon PriorBDS, MS, PhD,
Cara RileyDMD, MS,
William JohnstonMS, PhD,
Megann SmileyDMD, MS, and
Sarat ThikkurissyDDS, MS
Article Category: Other
Volume/Issue: Volume 60: Issue 4
Online Publication Date: Jan 01, 2013
DOI: 10.2344/0003-3006-60.4.162
Page Range: 162 – 177

of a single ideal technique. Additionally, the need and demand for sedation services is on the rise. The search of an ideal sedative agent is centered on the ability to provide amnesia, anxiolysis, and analgesia while providing both practitioner and patient satisfaction. Rapid onset and offset, ease in adjustability, wide margin of safety, and a high-quality procedural sedation are other desirable features. Fospropofol, which is a new sedative/hypnotic agent, is being evaluated for potential benefits compared to existing drugs such as a well-known and widely used

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Figure 1. ; Duration of surgery.
Philip Yen,
Simon Prior,
Cara Riley,
William Johnston,
Megann Smiley, and
Sarat Thikkurissy
<bold>Figure 1.</bold>
Figure 1.

Duration of surgery.

Figure 2. ; Supplemental doses to induce.
Philip Yen,
Simon Prior,
Cara Riley,
William Johnston,
Megann Smiley, and
Sarat Thikkurissy
<bold>Figure 2.</bold>
Figure 2.

Supplemental doses to induce.

Figure 3. ; Onset to sedation.
Philip Yen,
Simon Prior,
Cara Riley,
William Johnston,
Megann Smiley, and
Sarat Thikkurissy
<bold>Figure 3.</bold>
Figure 3.

Onset to sedation.

Figure 4. ; Supplemental doses after 30 minutes.
Philip Yen,
Simon Prior,
Cara Riley,
William Johnston,
Megann Smiley, and
Sarat Thikkurissy
<bold>Figure 4.</bold>
Figure 4.

Supplemental doses after 30 minutes.

Figure 5. ; Time to cognitive recovery.
Philip Yen,
Simon Prior,
Cara Riley,
William Johnston,
Megann Smiley, and
Sarat Thikkurissy
<bold>Figure 5.</bold>
Figure 5.

Time to cognitive recovery.

Figure 6. ; Time to physical recovery.
Philip Yen,
Simon Prior,
Cara Riley,
William Johnston,
Megann Smiley, and
Sarat Thikkurissy
<bold>Figure 6.</bold>
Figure 6.

Time to physical recovery.

Figure 7. ; Surgeon satisfaction.
Philip Yen,
Simon Prior,
Cara Riley,
William Johnston,
Megann Smiley, and
Sarat Thikkurissy
<bold>Figure 7.</bold>
Figure 7.

Surgeon satisfaction.

Figure 8. ; Patient satisfaction over 2 days.
Philip Yen,
Simon Prior,
Cara Riley,
William Johnston,
Megann Smiley, and
Sarat Thikkurissy
<bold>Figure 8.</bold>
Figure 8.

Patient satisfaction over 2 days.

Figure 9. ; Incidence of procedural recall.
Philip Yen,
Simon Prior,
Cara Riley,
William Johnston,
Megann Smiley, and
Sarat Thikkurissy
<bold>Figure 9.</bold>
Figure 9.

Incidence of procedural recall.