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Does Granisetron Eliminate the Gag Reflex? A Crossover, Double-Blind, Placebo-Controlled Pilot Study
![Figure 1](/view/journals/anpr/56/1/inline-i0003-3006-56-1-3-f01.jpeg)
The change in swab insertion depth was measured following administration of drug (black) and placebo (grey). The figure shows that both drug and placebo caused a significant increase in the volunteer's handling of the swab insertion.
![Figure 2](/view/journals/anpr/56/1/inline-i0003-3006-56-1-3-f02.jpeg)
Depths of swab insertion in male (a) and female (b) volunteers following drug (black) and placebo (white) administration. The females, who received higher dosages because of lower body mass, showed a more significant increase in drug action contrary to placebo.
![Figure 3](/view/journals/anpr/56/1/inline-i0003-3006-56-1-3-f03.jpeg)
A logarithmic reduction of changes in depth following administration of drug and placebo shows a positive trend in the increase of drug efficacy correlated with the increase in dosage per kilogram. The placebo does not follow the same trend. The increase in drug effectiveness is best seen in doses greater than ∼45 µg/kg.
![Figure 4](/view/journals/anpr/56/1/inline-i0003-3006-56-1-3-f04.jpeg)
Subtraction of the placebo effect from the drug effect shows that in females, whose average weight was lower (and thus the dosage per kilogram was higher), a significant increase was seen in drug efficacy proportional to the increase in dosage per kg (P < .031).