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Does Granisetron Eliminate the Gag Reflex? A Crossover, Double-Blind, Placebo-Controlled Pilot Study
Silvina Friedlander BarenboimDMD,
Vladislav Dvoyris, and
Eliezer KaufmanDMD
Article Category: Research Article
Volume/Issue: Volume 56: Issue 1
Online Publication Date: Jan 01, 2009
DOI: 10.2344/0003-3006-56.1.3
Page Range: 3 – 8

acupuncture, 8 9 hypnosis, 10 and combinations of these. 11 12 Selective 5-HT 3 antagonists were synthesized for palliative treatment of patients during antineoplastic treatment. 13 The drug of choice in such cases is ondansetron (Zofran), which has been used since the beginning of the 1990s. 14 This drug and other 5-HT 3 antagonists (palonosetron, dolasetron, granisetron, and tropisetron) are given enterally or parenterally and influence the peripheral and central nervous system in prevention of emesis. Their primary use is in preventing nausea and emesis

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Figure 1; The change in swab insertion depth was measured following administration of drug (black) and placebo (grey). The figure shows that both drug and placebo caused a significant increase in the volunteer's handling of the swab insertion.
Silvina Friedlander Barenboim,
Vladislav Dvoyris, and
Eliezer Kaufman
Figure 1
Figure 1

The change in swab insertion depth was measured following administration of drug (black) and placebo (grey). The figure shows that both drug and placebo caused a significant increase in the volunteer's handling of the swab insertion.

Figure 2; Depths of swab insertion in male (a) and female (b) volunteers following drug (black) and placebo (white) administration. The females, who received higher dosages because of lower body mass, showed a more significant increase in drug action contrary to placebo.
Silvina Friedlander Barenboim,
Vladislav Dvoyris, and
Eliezer Kaufman
Figure 2
Figure 2

Depths of swab insertion in male (a) and female (b) volunteers following drug (black) and placebo (white) administration. The females, who received higher dosages because of lower body mass, showed a more significant increase in drug action contrary to placebo.

Figure 3; A logarithmic reduction of changes in depth following administration of drug and placebo shows a positive trend in the increase of drug efficacy correlated with the increase in dosage per kilogram. The placebo does not follow the same trend. The increase in drug effectiveness is best seen in doses greater than ∼45 µg/kg.
Silvina Friedlander Barenboim,
Vladislav Dvoyris, and
Eliezer Kaufman
Figure 3
Figure 3

A logarithmic reduction of changes in depth following administration of drug and placebo shows a positive trend in the increase of drug efficacy correlated with the increase in dosage per kilogram. The placebo does not follow the same trend. The increase in drug effectiveness is best seen in doses greater than ∼45 µg/kg.

Figure 4; Subtraction of the placebo effect from the drug effect shows that in females, whose average weight was lower (and thus the dosage per kilogram was higher), a significant increase was seen in drug efficacy proportional to the increase in dosage per kg (P < .031).
Silvina Friedlander Barenboim,
Vladislav Dvoyris, and
Eliezer Kaufman
Figure 4
Figure 4

Subtraction of the placebo effect from the drug effect shows that in females, whose average weight was lower (and thus the dosage per kilogram was higher), a significant increase was seen in drug efficacy proportional to the increase in dosage per kg (P < .031).

New Center for Sedation and Anesthesiology Dedicated
Article Category: Research Article
Volume/Issue: Volume 55: Issue 3
Online Publication Date: Jan 01, 2008
DOI: 10.2344/0003-3006-55.3.101
Page Range: 101 – 103

,” and before dinner, Dr Sharon Eland of Israel compared “The Cardiovascular Effect of Articaine Versus Lidocaine in Medically Compromised Cardiac Patients: A Prospective, Randomized, Double Blind Study.” The next morning the conference resumed in the seacoast city of Herzliya, Israel at the Airforce Conference Center. The program featured the following contributors: Dr Elinor Bouvy-Berends of The Netherlands spoke on “Assessing Pain in Children With (Profound) Cognitive Impairment.” Dr Silvina Friedlander-Barenboim presented “Does Granisetron Eliminate the Gag