the need for additional support or treatment. In general, hemolysis is seen 1 to 3 days after contact with triggering factors. Acute hemolysis is self-limited, but in rare instances it can be severe enough to warrant a blood transfusion. 24 The patient may develop cyanosis, headache, fatigue, tachycardia, dyspnea, lethargy, lumbar/substernal pain, abdominal pain, splenomegaly, hemoglobinuria, and/or scleral icterus. 3 , 23 , 25 Also, the breakdown products of hemoglobin will accumulate in the blood, causing jaundice, and they can be excreted in the urine, causing