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Figure 1; Changes in blood pressure. In group D, systolic blood pressure (SBP) was significantly higher than that in group P. SBP and diastolic blood pressure (DBP) significantly decreased during maintenance administration compared with pretreatment value in groups D.

Kiichi Taniyama,

Hideki Oda,

Kazuko Okawa,

Katsuhito Himeno,

Koki Shikanai, and

Tohru Shibutani

Figure 1

Changes in blood pressure. In group D, systolic blood pressure (SBP) was significantly higher than that in group P. SBP and diastolic blood pressure (DBP) significantly decreased during maintenance administration compared with pretreatment value in groups D.

Figure 2; Changes in heart rate. In group D, heart rate significantly decreased from 6 minutes after the start of initial loading until the start of maintenance administration. Heart rate in group D was lower than that in group P.

Kiichi Taniyama,

Hideki Oda,

Kazuko Okawa,

Katsuhito Himeno,

Koki Shikanai, and

Tohru Shibutani

Figure 2

Changes in heart rate. In group D, heart rate significantly decreased from 6 minutes after the start of initial loading until the start of maintenance administration. Heart rate in group D was lower than that in group P.

Figure 3; Changes in percutaneous arterial blood oxygen saturation (SpO2). In group D, SpO2 significantly decreased from 6 minutes after the start of administration until the end of maintenance administration. SpO2 in Group D was significantly lower than that in Group P.

Kiichi Taniyama,

Hideki Oda,

Kazuko Okawa,

Katsuhito Himeno,

Koki Shikanai, and

Tohru Shibutani

Figure 3

Changes in percutaneous arterial blood oxygen saturation (SpO₂). In group D, SpO₂ significantly decreased from 6 minutes after the start of administration until the end of maintenance administration. SpO₂ in Group D was significantly lower than that in Group P.

Figure 4; Changes in bispectral index (BIS). At the optimum sedation level, BIS was significantly lower than pretreatment values in the 2 groups. During maintenance administration, the fluctuation of BIS in Group D was greater than that in Group P.

Kiichi Taniyama,

Hideki Oda,

Kazuko Okawa,

Katsuhito Himeno,

Koki Shikanai, and

Tohru Shibutani

Figure 4

Changes in bispectral index (BIS). At the optimum sedation level, BIS was significantly lower than pretreatment values in the 2 groups. During maintenance administration, the fluctuation of BIS in Group D was greater than that in Group P.