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General Anesthetic Management of a Patient With Kleine-Levin Syndrome
Masatoshi FujitaDDS, PhD and
Kentaro MizutaDDS, PhD
Article Category: Case Report
Volume/Issue: Volume 69: Issue 1
Online Publication Date: Apr 04, 2022
DOI: 10.2344/anpr-68-03-11
Page Range: 39 – 41

Kleine-Levin syndrome (KLS) is a rare sleep disorder first described more than 90 years ago. 1 , 2 Its prevalence is estimated at 1 to 5 cases per million. 3 KLS is characterized by recurrent episodes of hypersomnia, behavioral or cognitive disturbances like hyperphagia (rapid consumption of a large amount of food), and hypersexuality. 4 Crises usually manifest at least once a year, ranging from 2 days to 4 weeks, during which patients with KLS can sleep ∼18 hours a day. 5 In contrast, there are no symptoms during crisis intervals. 4

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Milad KaramlouDDS,
Iman AsariaDDS,
Jaime BarronDDS,
Petra BoutrosDMD,
Vincent FisherDDS,
Rachel GrandinettiDMD,
Julian JohnsonDMD,
Emily RichardDMD,
David SuskoDMD,
Cristobal UrrutiaDDS,
Bryce WoolseyDDS,
Ronald BaumannDDS,
James CottleDDS,
Richard SweaneyDDS,
Mark WenzelDDS,
John NussteinDDS, MS, and
David HallDDS
Article Category: Case Report
Volume/Issue: Volume 69: Issue 4
Online Publication Date: Dec 19, 2022
Page Range: 26 – 31

chest compressions, which required surgical repair. Other DM-related complications experienced by this patient during this 97-day hospital admission included cardiac dysrhythmias, hypersomnia, aspiration pneumonitis, and pneumonia. The patient was ultimately transferred to a long-term care facility and 3 months later suffered a fall that resulted in a fatal traumatic brain injury. DISCUSSION DM patients' primary defect is in muscle membranes (sarcolemmas) involving both sodium and chloride channels. 4 , 10 , 11 Atrophy of muscle