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Local Anesthetic Efficacy in Marijuana Users and Nonusers: A Pilot Study
Michael C. MoranDDS, MSD,
Lisa J. HeatonPhD,
Brian G. LerouxPhD, and
Natasha M. FlakeDDS, PhD, MSD
Article Category: Research Article
Volume/Issue: Volume 69: Issue 4
Online Publication Date: Dec 19, 2022
DOI: 10.2344/anpr-69-02-08
Page Range: 15 – 21

reports investigating the efficacy of local anesthetics related to marijuana use. This is surprising, given the widespread use of marijuana and continually evolving landscape of its legality at the state level within the United States. Marijuana is the most commonly used substance after tobacco and alcohol. 7 In the 2018 National Survey of Drug Abuse and Health, 34.8% of adults ages 18 to 25 and 13.3% of adults ages 26 or older had used marijuana in the past year. 7 Legalization and reduction in stigma may increase the likelihood that patients will report cannabis use

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Figure 1.; Flowchart of subject screening and testing protocol.
Michael C. Moran,
Lisa J. Heaton,
Brian G. Leroux, and
Natasha M. Flake
Figure 1.
Figure 1.

Flowchart of subject screening and testing protocol.


Michael C. Moran,
Lisa J. Heaton,
Brian G. Leroux, and
Natasha M. Flake
Figure 2.
Figure 2.

Subject screening and participation results.


Michael C. Moran,
Lisa J. Heaton,
Brian G. Leroux, and
Natasha M. Flake
Figure 3.
Figure 3.

Individual data points, median, and range for dental anxiety, anesthetic onset, and anesthetic duration. There were no significant differences between the groups for Modified Dental Anxiety Scale (MDAS) scores (P = .749), anesthetic onset (P = .432), or anesthetic duration (P = .708).


Robert J. MillerDO and
Mark A. GerhardtMD, PhD
Article Category: Other
Volume/Issue: Volume 53: Issue 1
Online Publication Date: Jan 01, 2006
Page Range: 13 – 16

are known to produce life-threatening angioedema of the upper airway structures when administered to patients with C1 esterase inhibitor deficiency. Individuals with alcohol addictions can develop angioedema by mechanisms that are not yet elucidated. Recreational drug use when self-administered via inhalation of hot gases can result in thermal trauma that can be isolated to the uvula. Uvula edema has been well documented after marijuana use. 3 Virtually any allergic reaction can result in angioedema and must be included in our differential diagnosis. Angioedema

All summaries and comments provided by Mark A SaxenDDS, PhD
Article Category: Research Article
Volume/Issue: Volume 67: Issue 1
Online Publication Date: Jan 01, 2020
Page Range: 60 – 62

-Villalobos M, Todeschini A, Stoicea N, Fiorda-Diaz J, Weaver T, Bergese S. Perioperative care of cannabis users: a comprehensive review of pharmacological and anesthetic considerations. J Clin Anesthesia . 2019;57:41–49. According to the 2015 National Survey on Drug Use and Health, marijuana continues to be the most common illicit recreational drug in the United States. Cannabinoids have multisystem effects that can interfere with anesthetic agents and lead to serious consequences. This comprehensive review examines the main physiological effects of cannabinoids and

Michelle WongDDS, MSc, EdD
Article Category: Case Report
Volume/Issue: Volume 68: Issue 2
Online Publication Date: Jun 29, 2021
Page Range: 98 – 106

. Known airway triggers included summer heat and humidity. Furthermore, she ingested cannabidiol 2 to 3 times weekly and vaped marijuana once per month for her other comorbidities. She occasionally used xylometazoline nasal sprays and saline rinses for allergic rhinitis and reported no known drug allergies. During her preanesthetic consultation and physical examination, she appeared well and not in distress. Assessment of her airway revealed full range of motion (cervical and temporomandibular joints), mouth opening and thyromental distance of 3 fingers' width

R. E. KastMD
Article Category: Case Report
Volume/Issue: Volume 52: Issue 3
Online Publication Date: Sep 01, 2005
Page Range: 102 – 104

tiagabine treatment of nocturnal bruxism is warranted. APPENDIX Standard sleep hygiene recommendations: Have no light, fan, television, radio, or other source of light or sound. This means not having a light-emitting diode clock or any way of telling what the time is. Try to keep regular hours. Go to bed at night and arise in the morning at the same time every day, including weekend days. Do not use tobacco, marijuana

Daniel E. BeckerDDS
Article Category: Research Article
Volume/Issue: Volume 57: Issue 4
Online Publication Date: Jan 01, 2010
Page Range: 150 – 157

Novel Agents Drugs that block the neurokinin 1 (NK 1 ) receptor have proven efficacy in chemotherapy-induced nausea and vomiting. They are most effective in preventing delayed nausea and generally are used in conjunction with 5-HT 3 antagonists for this reason. Aprepitant (Emend) is the first of these agents to be introduced, but its efficacy for PONV is not established. Likewise, the cannabinols such as tetrahydrocannabinol found in marijuana and dronabinol (Marinol), a synthetic derivative, have proven efficacy only for chemotherapy-induced nausea and

Zachary A. HellerDO, DMD,
Edward C. Adlesic MSDMD, and
Jason E. Portnof DMDMD
Article Category: Research Article
Volume/Issue: Volume 69: Issue 2
Online Publication Date: Jul 18, 2022
Page Range: 41 – 52

M, Eiden RD, Chang YP. Adolescent e-cigarette use trajectories and subsequent alcohol and marijuana use . Addict Behav . 2020 ; 103 : 106213 . doi: 10.1016/j.addbeh.2019.106213 8. Kautto A, Vehkalahti MM