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Anesthetic Efficacy of Lidocaine/Meperidine for Inferior Alveolar Nerve Blocks

Amanda Goodman DDS, MS,

Al Reader DDS, MS,

John Nusstein DDS, MS,

Mike Beck DDS, MA, and

Joel Weaver DDS, PhD

Article Category: Research Article

Volume/Issue: Volume 53: Issue 4

Online Publication Date: Jan 01, 2006

DOI: 10.2344/0003-3006(2006)53[131:AEOMFI]2.0.CO;2

Page Range: 131 – 139

. Meperidine was first introduced in 1939 as an analgesic, sedative, and antispasmodic agent. 21 It is also known as pethidine or Demerol. Meperidine is a phenylpiperidine derivative of the opioids. 22 23 The molecular weight and pKa of meperidine are closer to lidocaine than other opioids. 22 Clinically, meperidine has local anesthetic activity. A number of clinical and experimental studies 24–36 have shown that meperidine induces spinal anesthesia and blocks action potentials, providing segmental and sensory blocks comparable to those provided by lidocaine. In

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Anesthetic Efficacy of Meperidine in Teeth With Symptomatic Irreversible Pulpitis

Ladan Mohajeri DDS, MS,

Farnaz Salehi DDS,

Payman Mehrvarzfar DDS, MS,

Hamide Arfaee DDS,

Behnam Bohluli DDS, MS, and

Reza Hamedy DDS

Article Category: Other

Volume/Issue: Volume 62: Issue 1

Online Publication Date: Jan 01, 2015

DOI: 10.2344/0003-3006-62.1.14

Page Range: 14 – 19

compared different anesthetic agents 13 or their concentrations 14 to improve their efficacy. Activating the opioid receptors peripherally in inflammatory conditions has become a new trend in research to manage postoperative pain. 15 Synergy between local anesthetics and opioids has become an interesting field of research recently. 16 Opioids are frequently added to local anesthetics in a variety of surgical procedures, eg, intrathecal application for minor surgery. 17 Meperidine or its derivatives, eg, pethidine (meperidine chloride) or norpethidine

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Efficacy of Midazolam/Meperidine vs Midazolam/Hydromorphone for Enteral Moderate Sedation in the Pediatric Dental Patient

Bryce W. Kinard DMD,

Andrew S. Zale DMD, MSD, and

Kenneth L. Reed DMD

Article Category: Research Article

Volume/Issue: Volume 71: Issue 1

Online Publication Date: May 03, 2024

DOI: 10.2344/22-00037

Page Range: 15 – 18

(nitrous oxide/oxygen), is used to achieve moderate levels of sedation during dental procedures. 3 Midazolam is one of the most used medications for enteral sedation in the pediatric dental field. However, its working time is limited, and it notably lacks any analgesic properties. 4 The addition of opioids such as meperidine has been used to overcome these deficiencies. 5 Recently, the use of meperidine has diminished due to its active metabolite, normeperidine, and negative side effects such as altered mental status, nervousness, myoclonus, seizures, delirium, and

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Figure 2.; Incidence of second molar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Amanda Goodman,

Al Reader,

John Nusstein,

Mike Beck, and

Joel Weaver

Figure 2.

Incidence of second molar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Figure 3.; Incidence of first molar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Amanda Goodman,

Al Reader,

John Nusstein,

Mike Beck, and

Joel Weaver

Figure 3.

Incidence of first molar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Figure 4.; Incidence of second premolar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Amanda Goodman,

Al Reader,

John Nusstein,

Mike Beck, and

Joel Weaver

Figure 4.

Incidence of second premolar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Figure 5.; Incidence of first premolar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Amanda Goodman,

Al Reader,

John Nusstein,

Mike Beck, and

Joel Weaver

Figure 5.

Incidence of first premolar anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Figure 6.; Incidence of lateral incisor anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Amanda Goodman,

Al Reader,

John Nusstein,

Mike Beck, and

Joel Weaver

Figure 6.

Incidence of lateral incisor anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Figure 7.; Incidence of central incisor anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

Amanda Goodman,

Al Reader,

John Nusstein,

Mike Beck, and

Joel Weaver

Figure 7.

Incidence of central incisor anesthesia as determined by lack of response to electrical pulp testing at the maximum setting (percentage of 80/80s) at each postinjection time interval for the lidocaine and lidocaine/meperidine solutions. Significant differences (P < .05) between the 2 anesthetic solutions are marked with an asterisk (*).

A Prospective Study of 2 Sedation Regimens in Children: Chloral Hydrate, Meperidine, and Hydroxyzine Versus Midazolam, Meperidine, and Hydroxyzine

Marianne M. Sheroan DMD, MS, MS,

Diane C. Dilley DDS,

Warner J. Lucas DDS, MD, and

William F. Vann DMD, PhD

Article Category: Research Article

Volume/Issue: Volume 53: Issue 3

Online Publication Date: Jan 01, 2006

DOI: 10.2344/0003-3006(2006)53[83:APSOSR]2.0.CO;2

Page Range: 83 – 90

), meperidine (M), and hydroxyzine (H). Hasty et al 7 reported excellent behavioral outcomes with this regimen and found this combination to be safe as assessed by pulse oximetery and capnography. A more recent and comprehensive retrospective review of 195 pediatric conscious sedations with the CH/M/H cocktail reported that 72% of the sedations were satisfactory and that adverse outcomes were few and minor under a strict protocol and use of oxygen supplementation. 8 In one retrospective study, 9 an 84% success rate was found when the regimen CH/M/H was used with N 2 O

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eISSN: 1878-7177

ISSN: 0003-3006