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combination of the following assessment methods was used: Meta-Analysis of Observational Studies in Epidemiology (MOOSE), 16 Strengthening the Reporting of Observational Studies in Epidemiology (STROBE), 17 and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). 14 The potential risk of bias in each study was determined as follows: (1) random sample selection, (2) definition of the inclusion and exclusion criteria of the study, (3) report of losses and monitoring, (4) validated measurements, and (5) statistical analysis. Studies that satisfied

Woolf and Chong 6 described some adverse effects related to the use of these medications such as gastrointestinal bleeding, renal function disturbances, reduction and platelet function, respiratory depression, and profound hypotension. The aim of this study was to conduct a systematized review of the literature about the use of nonsteroidal anti-inflammatory agents as preemptive analgesics administered orally in third-molar surgeries and to evaluate the outcome of their clinical effectiveness by means of meta-analysis. METHODS A literature

nitrous oxide with midazolam is also used. This may bring about the beneficial effects of acceptance of the nitrous oxide mask and a decrease in the dose of midazolam used. Nitrous oxide sedation, which frequently reduces stress and anxiety in children undergoing dental treatment, is also commonly accepted by parents. 5 Hence, this systematic review and meta-analysis of randomized controlled trials aims to identify the level of sedation produced by a combination of nitrous oxide and parenteral midazolam in both adults and children. MATERIALS AND

controlled trials (RCTs). To compare the relative risk of anesthetic airway complications between intubated and nonintubated (LMA) patients under GA for dental procedures in RCTs. METHODS In this review, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) criteria. 14 Inclusion and Exclusion Criteria We included RCTs that would match the following Population, Intervention, Comparison, Outcomes, and Study design (PICOS) framework

between anesthetic agents used during LMA insertion following GA induction. We performed a systematic review and network meta-analysis (NMA) comparing propofol as the sole anesthetic for GA induction with other anesthetic combinations used during LMA insertion. Our primary outcome was prolonged apnea, and our secondary outcomes were airway adverse events, LMA insertion failure, inadequate anesthetic depth, adverse hemodynamic events, unanticipated hospital admission, and patient mortality. Anesthesia practice among clinicians is diverse in their selection of drug

the success rate of IANB and the lack of any systematic review on this issue justify conducting the present study. Therefore, this study was designed as a systematic review and meta-analysis of the available evidence to answer the question whether 3.6-mL volume of an anesthetic agent is more effective than 1.8-mL volume in providing anesthesia for mandibular molar teeth. METHODS This systematic review and meta-analysis followed the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. 20 , 21