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Diversity of Opioid Requirements for Postoperative Pain Control Following Oral Surgery—Is It Affected by Polymorphism of the μ-Opioid Receptor?
Ken-ichi FukudaDDS, PhD,
Masakazu HayashidaMD, PhD,
Kazutaka IkedaPhD,
Yoshihiko KoukitaDDS, PhD,
Tatsuya IchinoheDDS, PhD, and
Yuzuru KanekoDDS, PhD
Article Category: Research Article
Volume/Issue: Volume 57: Issue 4
Online Publication Date: Jan 01, 2010
DOI: 10.2344/0003-3006-57.4.145
Page Range: 145 – 149

requirements by examining, respectively, the effect of polymorphisms in the μ-opioid receptor gene and that of preoperative anxiety on postoperative pain (fentanyl requirement). This report describes the background and current progress of our study. BACKGROUND Selection and Setting of Target Surgery Individual differences in sensitivity to pain are preferably examined in healthy subjects. If sensitivity to analgesics for postoperative pain control is to be examined, pathological condition, degree of surgical invasiveness

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Figure 1; Changes in operative time for sagittal split mandibular osteotomy and volume of intraoperative bleeding are shown.
Ken-ichi Fukuda,
Masakazu Hayashida,
Kazutaka Ikeda,
Yoshihiko Koukita,
Tatsuya Ichinohe, and
Yuzuru Kaneko
Figure 1
Figure 1

Changes in operative time for sagittal split mandibular osteotomy and volume of intraoperative bleeding are shown.

Figure 2; Frequency of need for postoperative analgesics following sagittal split mandibular osteotomy (SSMO) compared with that following oral soft tissue surgery.
Ken-ichi Fukuda,
Masakazu Hayashida,
Kazutaka Ikeda,
Yoshihiko Koukita,
Tatsuya Ichinohe, and
Yuzuru Kaneko
Figure 2
Figure 2

Frequency of need for postoperative analgesics following sagittal split mandibular osteotomy (SSMO) compared with that following oral soft tissue surgery.

Figure 3; Measurement of latency to pain perception before (PPLpre) and after (PPLpost) administration of fentanyl. (A patient's hand was immersed in ice-cold water so that more than half of the area of the dorsum of the hand was underwater.)
Ken-ichi Fukuda,
Masakazu Hayashida,
Kazutaka Ikeda,
Yoshihiko Koukita,
Tatsuya Ichinohe, and
Yuzuru Kaneko
Figure 3
Figure 3

Measurement of latency to pain perception before (PPLpre) and after (PPLpost) administration of fentanyl. (A patient's hand was immersed in ice-cold water so that more than half of the area of the dorsum of the hand was underwater.)

Figure 4; Intraoperative and postoperative procedures.
Ken-ichi Fukuda,
Masakazu Hayashida,
Kazutaka Ikeda,
Yoshihiko Koukita,
Tatsuya Ichinohe, and
Yuzuru Kaneko
Figure 4
Figure 4

Intraoperative and postoperative procedures.

Figure 5; Relationships between analgesic efficacy of fentanyl (%MPE) and A118G genotypes.
Ken-ichi Fukuda,
Masakazu Hayashida,
Kazutaka Ikeda,
Yoshihiko Koukita,
Tatsuya Ichinohe, and
Yuzuru Kaneko
Figure 5
Figure 5

Relationships between analgesic efficacy of fentanyl (%MPE) and A118G genotypes.

Figure 6; Relationships between postoperative consumption of fentanyl (patient-controlled analgesia [PCA]) and A118G genotypes.
Ken-ichi Fukuda,
Masakazu Hayashida,
Kazutaka Ikeda,
Yoshihiko Koukita,
Tatsuya Ichinohe, and
Yuzuru Kaneko
Figure 6
Figure 6

Relationships between postoperative consumption of fentanyl (patient-controlled analgesia [PCA]) and A118G genotypes.

Figure 7; Relationship between postoperative consumption of fentanyl (patient-controlled analgesia [PCA]) and preoperative anxiety level (state-trait anxiety inventory [STAI]).
Ken-ichi Fukuda,
Masakazu Hayashida,
Kazutaka Ikeda,
Yoshihiko Koukita,
Tatsuya Ichinohe, and
Yuzuru Kaneko
Figure 7
Figure 7

Relationship between postoperative consumption of fentanyl (patient-controlled analgesia [PCA]) and preoperative anxiety level (state-trait anxiety inventory [STAI]).

Figure 8; Relationship between visual analog scale (VAS) at 24 hours postoperatively and preoperative anxiety level (state-trait anxiety inventory [STAI]).
Ken-ichi Fukuda,
Masakazu Hayashida,
Kazutaka Ikeda,
Yoshihiko Koukita,
Tatsuya Ichinohe, and
Yuzuru Kaneko
Figure 8
Figure 8

Relationship between visual analog scale (VAS) at 24 hours postoperatively and preoperative anxiety level (state-trait anxiety inventory [STAI]).

Effects of Lidocaine and Articaine on Neuronal Survival and Recovery
Farraj AlbalawiBDS,
Jason C. LimBS,
Kyle V. DiRenzo,
Elliot V. HershDMD, MS, PhD, and
Claire H. MitchellPhD
Article Category: Research Article
Volume/Issue: Volume 65: Issue 2
Online Publication Date: Jan 01, 2018
DOI: 10.2344/anpr-65-02-02
Page Range: 82 – 88

the cells into the range of Ca 2+ channel activation. While the precise site of action cannot be determined without direct inspection of the ionic currents, the parallel findings with the 2 assays imply articaine is not affecting the cells. Although the results of the current study suggest articaine is no more disruptive than lidocaine to neural cells, there are several other mechanisms that could underlie differential rates of paresthesia reported in the literature. For example, the low overall occurrence suggests that genetic polymorphisms in the ionic