assess the quality and confidence in the main results of pooled data, 2 review authors (J.P. and M.Z.) used the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) assessment tool (GRADEpro GDT, McMaster University, 2015; developed by Evidence Prime, Inc; available from gradepro.org). Five domains of study limitations—risk of bias, inconsistency, indirectness, imprecision, publication bias, and overall certainty of bias—were evaluated. Each domain's risk level was judged as very severe, severe, or no concerns. This either downgraded or upgraded