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![Figure 1.](/view/journals/anpr/61/4/inline-i0003-3006-61-4-135-f01.png)
Flowchart of experimental design. Gel I and II are lidocaine 2% and placebo gel, and subjects were randomized to testing order (cross-over). Gel application time was 5 minutes. MPT indicates mechanical pain threshold; PPT, pressure pain threshold; MPS, mechanical pain sensitivity—self-report of pain and discomfort during pinprick stimulus; and NPS, needle penetration sensitivity—self-report of pain and discomfort during needle penetration of oral mucosa.
![Figure 2.](/view/journals/anpr/61/4/inline-i0003-3006-61-4-135-f02.png)
Mean values and standard deviations of the mechanical pain threshold (MPT; g) for lidocaine and placebo at the 0, and 10-, 20-, and 30-minute assessments (n = 29).
![Figure 3.](/view/journals/anpr/61/4/inline-i0003-3006-61-4-135-f03.png)
Mean values and standard deviations of the pressure pain threshold (PPT; kPa) for lidocaine and placebo at the 0, and 10-, 20-, and 30-minute assessments (n = 29).
![Figure 4.](/view/journals/anpr/61/4/inline-i0003-3006-61-4-135-f04.png)
Mean values and standard deviations of mechanical pain sensitivity (MPS; visual analog scale) for lidocaine and placebo at the 0, and 10-, 20-, and 30-minute assessments; (a) pain intensity and (b) discomfort (n = 29).
![Figure 5.](/view/journals/anpr/61/4/inline-i0003-3006-61-4-135-f05.png)
Mean values and standard deviations of needle penetration sensitivity (NPS; visual analog scale) for lidocaine and placebo at the 0, and 10-, 20-, and 30-minute assessments; (a) pain intensity and (b) discomfort (n = 29).