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surveyed had treatment that included administration of antidepressants. 5 Antidepressants are a broad and expansive group of medications, but the more common drug classes include tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs). A miscellaneous or “atypical” category covers other agents. The administration of sedation or general anesthesia may mitigate acute situational anxiety as it relates to dental procedures. It is important for

Part I of this series discussed antidepressant pharmacology and interactions with adrenergic agonists. In part II, we will focus on Sedation and General Anesthetic Drug Interactions, Serotonin Syndrome, and other anesthetic concerns with antidepressants. SEDATION AND GENERAL ANESTHETIC DRUG INTERACTIONS Tricyclic Antidepressants (TCAs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) As noted in part I, both the TCAs and the SNRIs inhibit the reuptake of both serotonin and

, 253 SNRI, 253 Somatosensory evoked potential, 73 Spiral tube, 171 SSRI, 253 St John's Wort, 253 Subcutaneous emphysema, 85 Submental, 153 Superior mesenteric artery syndrome, 244 TCA, 253 Temperament, 17 Tension pneumothorax, 85 Third molars, 8, 80, 127, 136 Tooth extraction, 127 Tricyclic antidepressants, 253 Trismus, 97 Trisomy 9 mosaic, 29 Trisomy 13, 162 Tube-related trouble, 171 Type 2

classes are commonly used as analgesics for chronic pains versus acute pain. These include antidepressants, particularly the tricyclic antidepressants (TCAs) 1 , 2 and the selective serotonin-norepinephrine reuptake inhibitors (SNRIs), 3 – 5 nonsteroidal anti-inflammatory agents (NSAIDs) when an inflammatory component is present, and the opioids. The latter 2 groups were discussed in the previous article, “Pain Management: Part I: Managing Acute and Postoperative Dental Pain.” 6 Only relevant issues associated with the use of these medications in chronic pain versus