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orthodontic mini-implant placement. 10 – 12 Therefore, more research of the use of CTA as an adjunct to intraoral local anesthetic injections is warranted. The aim of this study was to evaluate the efficacy of a CTA using 10% lidocaine, 10% prilocaine, and 4% tetracaine, which has been trademarked as Profound ® , in comparison with 20% benzocaine. 13 METHODS The hypothesis for this pilot study was that use of a CTA comprising 10% lidocaine, 10% prilocaine, and 4% tetracaine would be more effective than a topical anesthetic with 20% benzocaine

intraoral dye marker. One of the 2 study drugs—20% benzocaine gel (HurriCaine Topical Anesthetic GEL, Beutlich LP Pharmaceuticals, Waukegan, Ill) or a combination product containing lidocaine 20%, tetracaine 4%, and phenylephrine 2% (TAC 20% Alternate Topical Anesthetic Gel Thick, Professional Arts Pharmacy, Lafayette, La)—was applied on the attached gingiva or alveolar mucosa overlying the intended anchorage site using a cotton-tipped applicator and was allowed to remain in contact with the tissue for the amount of time prescribed by the manufacturer (1.0 and 2.5 minutes

teeth although restorations, caries, or significant pulp calcifications may interfere with the Doppler effect, decreasing LDF accuracy. 8 Previous studies utilizing LDF have shown a PBF decrease following the use local anesthetics in combination with sympathomimetic agents. 9 – 11 In June 2016, the US Food and Drug Administration approved Kovanaze nasal spray (KNS) for clinical use in dentistry. It contains 3% tetracaine (an ester local anesthetic) and 0.05% oxymetazoline (a topical decongestant and sympathomimetic) and is designed for intranasal

; and (c) an intermediate chain connecting the aromatic and amino termini. The latter structure divides the local anesthetic into 2 different groups: esters (-COO-) and amides (-NHCO-). Esters, such as procaine and tetracaine, are metabolized by plasma pseudocholinesterase. 2 This group of dental local anesthetics is no longer available in dental cartridges. However, a nasal spray formulation to provide maxillary anesthesia containing 3% tetracaine and 0.05% oxymetazoline, a vasoconstrictor, was approved by the US Food and Drug Administration on June 29, 2016, for a

cotton wool ball for 7 minutes 1 ; and with the CTA-Oraqix dispenser, in which the topical anesthetic comes preloaded in a carpule and a cotton applicator from the manufacturer, for 3 minutes. 16 The majority of the studies used different quantities, concentrations, and anesthetic formulations, which included compound topical anesthetic (CTA), conventional topical anesthetic (TA), and injectable infiltrative anesthetic (IA). The various anesthetic formulations included 0.18 g (calculated to be ∼ 0.7 mL) of CTA with 10% prilocaine, 10% lidocaine, 4% tetracaine

of Topical Anesthetic Activities of Several Agents Using Starch Wafer Method Abstract Application of topical anesthetics shielded by a starch wafer (the starch wafer method) and the conventional application method were compared in terms of degree of pain during needle insertion, occurrence of a bitter taste, and leakage of the agent. A total of 105 subjects (24.5±4.0 years) were enrolled in the study, and 7 commercially available topical anesthetics, Copalon ® (6% tetracaine hydrochloride; K-Solution), Hurricaine ® Gel (20% ethyl

Intravenous (IV) catheters have become the accepted standard of care for general anesthesia and IV sedation. 1 Catheterization of peripheral veins can be made more comfortable using a variety of techniques, including local anesthesia infiltration, 2 3 nitrous oxide inhalation, 2 4 5 ethyl chloride topical, 4 6 eutectic mixture of local anesthetics (lidocaine-prilocaine) cream, 7 8 tetracaine patches, 9 and even midazolam nasal spray. 10 The goals of these methods are pain and anxiety reduction with minimal invasiveness and lack of

significant improvement. Cocaine and tetracaine have been commonly used intranasally to provide anesthesia (both drugs) or vasoconstriction (cocaine only) prior to surgical procedures in otolaryngology in the extremely vascular nasal cavity or prior to passage of a tube through the nares (nasotracheal intubation). Other vasoconstrictors (phenylephrine, oxymetazoline) are frequently sprayed into the nasal cavity to relieve nasal congestion. Spraying a combination of tetracaine and oxymetazoline into the nares has been successful in providing pulpal anesthesia of the