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Lidocaine Tape Application for 3 Hours Prevents Vasovagal Syncope During Venipuncture: A Case Series
Kaho ShiraishiDDS,
Takashi GotoDDS, PhD,
Shoko OyaDDS,
Shintaro HayashiDDS, PhD, and
Satoru SakuraiDDS, PhD
Article Category: Brief Report
Volume/Issue: Volume 70: Issue 1
Online Publication Date: Mar 28, 2023
DOI: 10.2344/anpr-70-01-03
Page Range: 34 – 36

Vasovagal syncope (VVS) can be triggered by emotional stress or pain even from relatively innocuous procedures like venipuncture and often occurs perioperatively. Not only can it be extremely uncomfortable or embarrassing for the patient, but it can also lead to postponement or case cancellation as well as more serious medical issues, especially in medically compromised patients. Thus, it is important to recognize and prevent VVS whenever possible. This case series presents the successful preoperative application of lidocaine tape to prevent

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Figure 2.; 60% Lidocaine Tape on Venipuncture Site Patients were directed to self-apply lidocaine tape containing 18 mg of lidocaine at the previously identified venipuncture site 3 hours prior to venipuncture.
Kaho Shiraishi,
Takashi Goto,
Shoko Oya,
Shintaro Hayashi, and
Satoru Sakurai
Figure 2.
Figure 2.

60% Lidocaine Tape on Venipuncture Site

Patients were directed to self-apply lidocaine tape containing 18 mg of lidocaine at the previously identified venipuncture site 3 hours prior to venipuncture.


Kaho Shiraishi,
Takashi Goto,
Shoko Oya,
Shintaro Hayashi, and
Satoru Sakurai
Figure 1.
Figure 1.

ECG Tracings Captured During VVS

ECG recorded (a) before IV start, (b) during VVS episode, and (c) after recovery. In Case 1, sinus arrest was observed for ∼12.7 seconds before the occurrence of escape rhythms (arrows). In Case 2, sinus arrest was observed for ∼3.4 seconds. ECG, electrocardiogram; VVS, vasovagal syncope.


Christy LamDDS,
Richard D. UdinDDS,
Stanley F. MalamedDDS,
David L. GoodDDS, and
Jane L. ForrestRDH, EdD
Article Category: Research Article
Volume/Issue: Volume 52: Issue 2
Online Publication Date: Jun 01, 2005
Page Range: 56 – 61

The induction of intravenous conscious sedation in pediatric patients undergoing extensive dental treatment may be a challenge, particularly during parental separation and venipuncture. The use of sedative premedication may help reduce the anxiety and minimize psychological trauma in these patients. Midazolam (Versed, Hoffman-La Roche Inc, Nutley, NJ) is an example of such a preoperative sedative agent. As a water-soluble benzodiazepine, midazolam is nonirritating and has anxiolytic, sedative, hypnotic, and amnesic properties. Midazolam has been used as a

David L. HallDDS,
Ehsan RezvanDDS,
Dimitris N. TatakisDDS, PhD, and
John D. WaltersDDS, MS
Article Category: Research Article
Volume/Issue: Volume 53: Issue 2
Online Publication Date: Jan 01, 2006
Page Range: 34 – 42

restroom facilities prior to sedation sessions because clonidine can exert a mild diuretic effect. 21 Patients breathed 4 L/min of 100% O 2 via nasal cannula during venipuncture. Recall and recognition were tested following at least 2 hours of intravenous conscious sedation and approximately 20 minutes of recovery (time = 200) via a post-session follow-up questionnaire and all original baseline measurements repeated. The sedationist and surgeon also completed postsession questionnaires. All subjects also completed a poststudy questionnaire immediately following

Keiko Fujii-AbeDDS, PhD,
Kazutaka UriuDDS, and
Hiroshi KawaharaDDS, PhD
Article Category: Case Report
Volume/Issue: Volume 62: Issue 4
Online Publication Date: Jan 01, 2015
Page Range: 159 – 161

sedation. She was lying on a dental chair in a supine position. Routine monitoring, including blood pressure (BP), arterial oxygen saturation (SpO 2 ), and an electrocardiogram (ECG), was conducted. Preoperative vital signs revealed a heart rate of 72 beats/min (bpm), BP of 126/74 mm Hg, and SpO 2 of 100% ( Figure 1 ). The first attempt at venipuncture was not successful. Immediately after the second venipuncture, the patient's heart rate was 68 bpm, BP was 124/84 mm Hg, and SpO 2 was 100%. We started propofol sedation (target concentration in blood 2.0 μg/mL) using a

Mikiko YamashiroDDS, PhD and
Hideki FuruyaDDS, PhD
Article Category: Other
Volume/Issue: Volume 53: Issue 1
Online Publication Date: Jan 01, 2006
Page Range: 17 – 19

venipuncture site. Sedation was started by inhalation of 50% N 2 O and 50% O 2 via a nasal cannula. A venous cannula was inserted in the right radial cutaneous vein and an infusion of acetate–Ringer's solution was started. Propofol 35 mg IV was administered as an induction dose followed by an infusion of 3 to 4 mg/kg/h for maintenance of sedation. We monitored blood pressure, pulse rate, SpO 2 , and ETCO 2 . After the patient's vital signs became stable, periodontal ligament injection with 2% lidocaine containing 1 : 80,000 epinephrine was administered to the maxillary left

Timothy M. OrrDMD and
Daniel L. Orr IIDDS, PhD, MD, JD
Article Category: Case Report
Volume/Issue: Volume 62: Issue 4
Online Publication Date: Jan 01, 2015
Page Range: 162 – 165

. Textbook of Medical Physiology . 11th ed . Philadelphia, Pa : Elsevier : 2006 : 151 – 154 . 7 Alijanian A , Bedrossian E , Feeney C , Devlin D. Asystole secondary to venipuncture: report of case . J Oral Maxillofac Surg . 2001 ; 59 : 461 – 462 . 8

Yoshiki ShionoyaDDS, PhD,
Kaoru HirayamaDDS,
Kaho SaitoDDS,
Eriko KawasakiDDS,
Yoko KantakeDDS,
Hazuki OkamotoDDS, PhD,
Takahiro GoiDDS,
Katsuhisa SunadaDDS, PhD, and
Kiminari NakamuraDDS, PhD
Article Category: Case Report
Volume/Issue: Volume 69: Issue 2
Online Publication Date: Jul 18, 2022
Page Range: 24 – 29

prevent venipuncture stress-induced arrhythmia, a lidocaine patch (Penles Tape 18 mg, Nitto Denko Corporation) was applied to the IV site 30 minutes before she entered the operating room appearing anxious. American Society of Anesthesiologists monitors were placed, consisting of a pulse oximeter, 3-lead ECG, and a noninvasive BP cuff. Her initial vital signs were as follows: BP 105/61 mm Hg; HR 55 bpm; and SpO 2 98% on room air. Oxygen 3 L/min was administered via nasal cannula. IV access was secured using a 22-gauge catheter placed in her left hand, and

Arthur C. DiMarcoDMD and
Ann O'Kelley WetmoreRDH, MSDH
Article Category: Research Article
Volume/Issue: Volume 63: Issue 2
Online Publication Date: Jun 01, 2016
Page Range: 55 – 61

effectiveness elsewhere in the oral cavity. 24 In a 2000 literature review of intraoral topical anesthetics, Meechan 25 discussed both positive and negative study results for a variety of application sites including the palate. There are more negative than positive studies cited for the palate, most having used placebos in addition to anesthetic agents for penetrations as well as injections of anesthetics. Refrigerants, or vapocoolants, have been used extensively in medicine for providing comfort prior to procedures that involve needles, such as venipunctures