The mean value of P1-N1 amplitudes of L group

The L group significantly decreased from 2 min to 35 min. During that time, the average was 32.8% of control value. The maximum reduction was seen at 4 min (21.6% of control)

The mean value of P1-N1 amplitudes of LD group

The LD group significantly decreased immediately after administration and throughout 120 min. During that time, the average was 13.3% of control value. The maximum reduction was seen at 50 min (7.5% of control)

The mean value of P1-N1 amplitudes of DX group

The DX group significantly decreased at 2, 4, and 8 min. During that time, the average was 47.9% of control value. The maximum reduction was seen at 4 min (44.6% of control)

The mean value of systolic pressure of L group

The L group did not show any significant change

The mean value of systolic pressure of LD group

The LD group did not show any significant change

The mean value of systolic pressure of DX group

The DX group significantly increased at 2 min, and decreased at 115 min

The mean value of diastolic pressure of L group

The L group did not show any significant change

The mean value of diastolic pressure of LD group

The LD group did not show any significant change

The mean value of diastolic pressure of DX group

The DX group significantly decreased from 45 min to 120 min

The mean value of heart rate of L group

The L group significantly decreased at 115 and 120 min

The mean value of heart rate of LD group

The LD group significantly decreased from 2 min to 120 min

The mean value of heart rate of DX group

The DX group significantly decreased from 2 min to 120 min

Schematic diagram

1) Administration of propitocaine with felypressin (FP) into labial gingiva of incisor tooth

2) A catheter was inserted into left ventricule via common carotid artery for CMS injection

3) A catheter was inserted into left femoral artery for CMS collection

4) A catheter was inserted into right femoral artery for measurement of heart rate and blood pressure

Time table of experimental steps

1) Inject CMS immediately after start of blood collection over 80 seconds

2) Measurement of heart rate and blood pressure before CMS injection

3) Administration of propitocaine with felypressin (FP) into gingiva

4) Inject CMS 5 minutes after administration of FP

5) Extract heart

Change of myocardial blood flow in left heart after administration of FP

There was no significant difference before and after FP administration.

p=0.134

Change of myocardial blood flow in right heart after administration of FP

There was no significant difference before and after FP administration.

p=0.069

Change of cardiac output after administration of FP

There was significant difference before and after FP administration.

p=0.0006

Change of heart rate after administration of FP

There was significant difference before and after FP administration.

p=0.049

Change of systolic blood pressure after administration of FP

There was significant difference before and after FP administration.

p=0.00006

Change after diastolic blood pressure after administration of FP

There was significant difference before and after FP administration.

p=0.0005

Pain scores in each groups

Columns represent median pain scores in each group and vertical lines represent 75 percentile + 1.5 × interquartile range (IQR).

The mean values of the pain score in all groups except group TF were significantly lower than in group LCT (control). No significant differences were found between groups L, F, and MCT/LCT. The score in group TL was lower than that in all other groups, being significantly lower than group L

Wong-Baker face scale used for evaluation of generalized comfort in the ICU and patient-perceived satisfaction regarding level of sedation

Degree of generalized comfort while under sedation

Degree of perceived satisfaction in ICU answered more than 24 hours after sedation

There was significant difference for degree 4 and 5, indication unsatisfied, between the groups

Degree of recall during sedation

There was significant difference for 'Slight recall' and 'No recall', indicating 'Amnesia (+)', between the groups

Comparison of anxiety scores before SSRO (T₁) and removal of miniplates (T₂)

State anxiety scores before removal of miniplates were significantly lower than those before SSRO

Correlation of state anxiety before SSRO (T₁) and removal of miniplates (T₂)

ECG changes

Appearances of paroxysmal atrial fibrillation and ventricular extra systole and its improvement by converting to the sinus rhythm after application of synchronized cardioversion under general anesthesia