The mean value of P1-N1 amplitudes of L group
The L group significantly decreased from 2 min to 35 min. During that time, the average was 32.8% of control value. The maximum reduction was seen at 4 min (21.6% of control)
The mean value of P1-N1 amplitudes of LD group
The LD group significantly decreased immediately after administration and throughout 120 min. During that time, the average was 13.3% of control value. The maximum reduction was seen at 50 min (7.5% of control)
The mean value of P1-N1 amplitudes of DX group
The DX group significantly decreased at 2, 4, and 8 min. During that time, the average was 47.9% of control value. The maximum reduction was seen at 4 min (44.6% of control)
The mean value of systolic pressure of L group
The L group did not show any significant change
The mean value of systolic pressure of LD group
The LD group did not show any significant change
The mean value of systolic pressure of DX group
The DX group significantly increased at 2 min, and decreased at 115 min
The mean value of diastolic pressure of L group
The L group did not show any significant change
The mean value of diastolic pressure of LD group
The LD group did not show any significant change
The mean value of diastolic pressure of DX group
The DX group significantly decreased from 45 min to 120 min
The mean value of heart rate of L group
The L group significantly decreased at 115 and 120 min
The mean value of heart rate of LD group
The LD group significantly decreased from 2 min to 120 min
The mean value of heart rate of DX group
The DX group significantly decreased from 2 min to 120 min
Schematic diagram
1) Administration of propitocaine with felypressin (FP) into labial gingiva of incisor tooth
2) A catheter was inserted into left ventricule via common carotid artery for CMS injection
3) A catheter was inserted into left femoral artery for CMS collection
4) A catheter was inserted into right femoral artery for measurement of heart rate and blood pressure
Time table of experimental steps
1) Inject CMS immediately after start of blood collection over 80 seconds
2) Measurement of heart rate and blood pressure before CMS injection
3) Administration of propitocaine with felypressin (FP) into gingiva
4) Inject CMS 5 minutes after administration of FP
5) Extract heart
Change of myocardial blood flow in left heart after administration of FP
There was no significant difference before and after FP administration.
p=0.134
Change of myocardial blood flow in right heart after administration of FP
There was no significant difference before and after FP administration.
p=0.069
Change of cardiac output after administration of FP
There was significant difference before and after FP administration.
p=0.0006
Change of heart rate after administration of FP
There was significant difference before and after FP administration.
p=0.049
Change of systolic blood pressure after administration of FP
There was significant difference before and after FP administration.
p=0.00006
Change after diastolic blood pressure after administration of FP
There was significant difference before and after FP administration.
p=0.0005
Pain scores in each groups
Columns represent median pain scores in each group and vertical lines represent 75 percentile + 1.5 × interquartile range (IQR).
The mean values of the pain score in all groups except group TF were significantly lower than in group LCT (control). No significant differences were found between groups L, F, and MCT/LCT. The score in group TL was lower than that in all other groups, being significantly lower than group L
Wong-Baker face scale used for evaluation of generalized comfort in the ICU and patient-perceived satisfaction regarding level of sedation
Degree of generalized comfort while under sedation
Degree of perceived satisfaction in ICU answered more than 24 hours after sedation
There was significant difference for degree 4 and 5, indication unsatisfied, between the groups
Degree of recall during sedation
There was significant difference for 'Slight recall' and 'No recall', indicating 'Amnesia (+)', between the groups
Comparison of anxiety scores before SSRO (T1) and removal of miniplates (T2)
State anxiety scores before removal of miniplates were significantly lower than those before SSRO
Correlation of state anxiety before SSRO (T1) and removal of miniplates (T2)
ECG changes
Appearances of paroxysmal atrial fibrillation and ventricular extra systole and its improvement by converting to the sinus rhythm after application of synchronized cardioversion under general anesthesia
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