Skip to main content
Sign inSign up

ADSA Society

Logo
IssuesFor AuthorsAdvertisingNewsHelp

ADSA Society

Article Contents

  • CASE STUDY
  • PHYSIOLOGY OF THE NEUROMUSCULAR JUNCTION
  • PHARMACOLOGY OF NEUROMUSCULAR BLOCKERS
  • DISCUSSION
  • CONCLUSION
  • REFERENCES
  • CONTINUING EDUCATION QUESTIONS
Save
Download PDF

Pseudocholinesterase deficiency, sometimes called butyrylcholinesterase deficiency, is a rare disorder in which the neuromuscular blocking drugs succinylcholine and mivacurium cannot be metabolized properly in the blood plasma. This disorder can either be acquired as a result of certain comorbidities or it can be inherited genetically. Anesthesia providers must understand the pathophysiology of pseudocholinesterase deficiency and be prepared to safely and effectively manage patients who show signs and symptoms consistent with the disorder after the use of the indicated neuromuscular blocking drugs. This article summarizes the pharmacologic and physiologic data relevant to understanding the basic pathophysiology associated with pseudocholinesterase deficiency and illustrates a case study of a young woman suspected of having the disorder after a prolonged delay in emergence from general anesthesia.

Keywords: Pseudocholinesterase deficiency; Butyrylcholinesterase deficiency; Residual neuromuscular blockade; Delayed emergence; General anesthesia
  • Download PDF
Copyright: © 2020 by the American Dental Society of Anesthesiology
Citations

Get Email Alerts

Article Contents
ANPR logo
AboutIssuesAuthor InformationSubscriptions

ADSA Society

eISSN: 1878-7177

ISSN: 0003-3006

Powered by PubFactory