Achieving profound pulpal anesthesia in permanent teeth diagnosed with irreversible pulpitis has always been problematic, with the limited success ranging between 60 and 80% with maxillary infiltration 1 , 2 to between 13 and 65% with inferior alveolar nerve block. 3 – 6 Researchers have been continuously searching for adjunctive therapies, such as supplementary injection, preemptive analgesia, and sedation, to improve the success of perceived pulpal anesthesia in these teeth. Ibuprofen, a nonsteroidal anti-inflammatory drug, has