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![<bold>Figure 4</bold>](/view/journals/anpr/66/4/inline-i0003-3006-66-4-192-f04.png)
Percentage of patients taking ibuprofen, ibuprofen/acetaminophen, and opioid. Opioid percentages are presented on top of the ibuprofen and ibuprofen/acetaminophen percentages.
![<bold>Figure 2</bold>](/view/journals/anpr/66/4/inline-i0003-3006-66-4-192-f02.png)
Percentages and discomfort ratings of postoperative pain for the ibuprofen and ibuprofen/acetaminophen groups by day. patients requiring opioids were excluded on days 2–4.
![<bold>Figure 3</bold>](/view/journals/anpr/66/4/inline-i0003-3006-66-4-192-f03.png)
Percentages and discomfort ratings of postoperative percussion pain for the ibuprofen and ibuprofen/acetaminophen groups by day. Patients requiring opioids were excluded on days 2–4.
![Figure 4](/view/journals/anpr/57/2/inline-i0003-3006-57-2-67-f04.png)
NSAID versus opioid analgesia. The following data were derived from patients who underwent third molar impaction surgery. See text for explanation.
(Ibu 400 = ibuprofen 400 mg; Oxy 5 = oxycodone 5 mg)
![Figure 2.](/view/journals/anpr/62/2/inline-i0003-3006-62-2-57-f02.png)
Response to use of nonsteroidal analgesics. *Ibuprofen and celecoxib, respectively, were considered analgesics separately. †There was no information available about the choice of patient by better response to NSAID or placebo used. Data represent the number of patients who did not make use of supplementary rescue analgesia.
![Figure 2](/view/journals/anpr/57/2/inline-i0003-3006-57-2-67-f02.png)
Analgesic efficacy. This graph illustrates a typical dose-response curve for orally administered (PO) analgesics. The dose-response curve for opioids such as morphine demonstrates unlimited efficacy in which greater doses provide greater analgesia. At equipotent doses, all opioids demonstrate a similar dose response. In contrast, nonopioids demonstrate a “ceiling” effect that generally is adequate for relief of mild to moderate pain (pain relief rating of 4–5 in this scale). For ibuprofen, doses greater than 400 mg do not provide further analgesia. For aspirin (ASA) and acetaminophen (APAP), this ceiling effect is achieved at 1000 mg and is somewhat lower than that provided by nonsteroidal anti-inflammatory drugs (NSAIDs).
![](/view/journals/anpr/53/3/inline-i0003-3006-53-3-78-f01.gif)