histamine, leading to a hypnotic state that is similar to that observed in normal sleep. 3 , 4 Unlike opioids, benzodiazepines, and propofol, dexmedetomidine has been shown not to depress respiration. 2 , 5 Dexmedetomidine has also been associated with reduced overall requirement for opioids, benzodiazepines, and propofol during intravenous sedation. 5 In addition, dexmedetomidine has been shown to potentiate opioids and reduce postoperative shivering. 6 , 7
Dexmedetomidine was initially recognized as an effective sedative in the intensive care unit for