Anatomy of the liver. (A) Anterior view. (B) Posteroinferior view. (Source: Figure 26.18 in McKinley & O'Loughlin's Human Anatomy, 2nd ed.)

Hepatic lobule. (A) Depiction of the hepatic lobules. (B) Arrangement of hepatocytes and hepatic sinusoids. (C) Histology of a portal tract. (Source: Figure 26.19 in McKinley & O'Loughlin's Human Anatomy, 2nd ed.)

Blood supply of a liver acinus. Oxygen tensions and nutrient levels within sinusoids continuously decrease as blood flows from zone 1 through zone 3. BD, bile ductule; CV, central vein; HA, hepatic artery; PV, portal vein. (Source: Jones AL. Anatomy of the normal liver. In: Zakim D, Boyer T, eds. Hepatology: A Textbook of Liver Disease. 3rd ed. 1996.)

Splanchnic circulation under fasting conditions. The liver receives most of its blood supply via the portal vein under fasting conditions. (Source: Barrett KE. Chapter 10. Functional anatomy of the liver and biliary system. In: Barrett KE, ed. Gastrointestinal Physiology, 2nd ed. 2014.)

Enterohepatic circulation. Bile secreted by hepatocytes enters the bile duct and flows through the biliary system to the duodenum. Conjugated bile acids are reabsorbed in the terminal ileum and recirculated through the portal vein back to the liver. (Source: Barrett KE. Chapter 10. Functional anatomy of the liver and biliary system. In: Barrett KE, ed. Gastrointestinal Physiology, 2nd ed. 2014.)