In the late 1950s and early 1960s, Peter Safar, MD, Professor and Chairman of the Department of Anesthesiology at the University of Pittsburgh School of Medicine, conducted research on resuscitation including opening the airway by tilting back the head and using mouth-to-mouth ventilation. He combined this with a separate procedure known as closed-chest cardiac massage, and the combination became the basic life support method now known as cardiopulmonary resuscitation (CPR). Although he is regarded as a father of CPR, Dr Safar was hesitant to take credit for inventing it, as he insisted that he had merely brought to light separate

Abstract

Cardiovascular effects of felypressin (FEL) were studied in Wistar rats. Heart rate and mean arterial pressure measurements were taken in awake rats treated with vasopressin (AVP), FEL, or epinephrine (EPI). Each group received either an intravenous (IV) or an intracerebroventricular V₁ receptor antagonist, saline, area postrema removal, or sham surgery. Analysis of variance and Student-Newman-Keuls (P < .05) were applied. Felypressin and AVP induced a pressor effect, and bradycardia was inhibited by IV V₁ antagonist. Intracerebroventricular V₁ antagonist and area postrema removal enhanced their pressor effects. Epinephrine induced a higher pressor effect and a similar bradycardia that was not affected by the treatments. It was concluded that FEL depends on V₁ receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V₁ receptors. These effects are potentially less harmful to the cardiovascular system than the effects of EPI.

Abstract

The purpose of this prospective, randomized, single-blinded, crossover study was to compare the pain of a traditional 1-stage inferior alveolar nerve (IAN) block injection to a 2-stage IAN block technique. Using a crossover design, 51 subjects randomly received, in a single-blinded manner, either the traditional IAN block or the 2-stage IAN block in 2 appointments spaced at least 1 week apart. For the 2-stage injection, the needle was inserted submucosally and 0.4 mL of 2% lidocaine with epinephrine was slowly given over 1 minute. After 5 minutes, the needle was reinserted and advanced to the target site (needle placement), and 1.8 mL of 2% lidocaine with epinephrine was deposited. For the traditional IAN block, following needle penetration, the needle was advanced while depositing 0.4 mL of 2% lidocaine with epinephrine (needle placement) and then 1.8 mL of 2% lidocaine with epinephrine was deposited at the target site. A Heft-Parker visual analogue scale was used to measure the pain of needle insertion, needle placement, and anesthetic solution deposition. There were no significant differences, as analyzed by Wilcoxon matched-pairs signed-ranks test, between needle insertion and solution deposition for the 2 techniques in men or women. However, there was significantly less pain with the 2-stage injection for needle placement in women. In conclusion, the 2-stage injection significantly reduced the pain of needle placement for women when compared to the traditional IAN technique.

Abstract

The authors, using a crossover design, randomly administered, in a single-blind manner, inferior alveolar nerve blocks using 36 mg of lidocaine with 18 μg of epinephrine or a combination of 36 mg of lidocaine with 18 μg epinephrine plus 36 mg meperidine with 18 μg of epinephrine, at 2 separate appointments, to 52 subjects. An electric pulp tester was used to test for anesthesia, in 4-minute cycles for 60 minutes, of the molars, premolars, and central and lateral incisors. Anesthesia was considered successful when 2 consecutive 80 readings were obtained within 15 minutes and the 80 reading was continuously sustained for 60 minutes. Using the lidocaine solution, successful pulpal anesthesia ranged from 8 to 58% from the central incisor to the second molar. Using the lidocaine/meperidine solution, successful pulpal anesthesia ranged from 0 to 17%. There was a significant difference (P < .05) between the lidocaine and lidocaine/meperidine solutions for the lateral incisors through the second molars. We conclude that the addition of meperidine to a standard lidocaine solution does not increase the success of the inferior alveolar nerve block.

Effect of Thermomechanical Stimulation on Pain During IANB Injections

Dharanshi AmlaniMDS,

Devendra NagpalMDS,

Pooja RathiMDS,

Gagandeep LambaMDS, PhD,

Purva ChaudhariMDS, and

Prabhat SinghMDS

Managing “Real” Anesthesia Emergencies on Human Simulators

Cardiovascular Effects of Felypressin

Abstract

The Effects of a 2-Stage Injection Technique on Inferior Alveolar Nerve Block Injection Pain

Abstract

Anesthetic Efficacy of Lidocaine/Meperidine for Inferior Alveolar Nerve Blocks

Abstract

Drug Therapy in Dental Practice: General Principles

Abstract

Effect of Thermomechanical Stimulation on Pain During IANB Injections

A Review of Current Literature of Interest to the Office-Based Anesthesiologist

General Anesthesia for a Child With a Living Donor Liver Transplant After Hepatoblastoma and Metastatic Lung Tumor Resection

A Case in Which the Hole in the Inflation Line Was Not Closed at the Tip of the Tracheal Tube

Commentary: Are Anesthesiologists Still “Darting” Their Patients?

Mistaken Endobronchial Placement of a Nasogastric Tube During Mandibular Fracture Surgery

The Effect of Intraoral Suction on Oxygen-Enriched Surgical Environments: A Mechanism for Reducing the Risk of Surgical Fires

Letter to the Editor

Monheim LM. Analgesia in dentistry now and in the future. Anesth Prog. 1971;18(5):100–106 and J Am Analg Soc. 1971:9:1(abstract).

A Review of Current Literature of Interest to the Office-Based Anesthesiologist