Abstract

The anti-inflammatory effects of ibuprofen and tramadol were investigated by measuring C-reactive protein concentrations after removal of an impacted lower third molar. Forty-five American Society of Anesthesiologists Class I patients were randomly categorized into 3 equal groups according to postoperative analgesic medication. The first group received tramadol (100 mg every 8 hours), the second group received ibuprofen (400 mg every 8 hours), and the last group received half doses of both drugs in combination (50 mg tramadol every 8 hours and 200 mg ibuprofen every 8 hours). C-reactive protein was measured before surgery to exclude the presence of any preexisting inflammatory condition that might interfere with the study. C-reactive protein was also determined immediately after surgery and 72 hours postoperatively. At 72 hours, C-reactive protein had increased over postsurgery baseline by 123% in the tramadol group (P < .001), 84% in the ibuprofen group (P < .001), and only 37% in the combined analgesic group (P = .078). These results suggest that tramadol may produce supra-additive anti-inflammatory effects with ibuprofen after third-molar extractions.

Abstract

The aim of this study was to compare both the behavioral and physiological effects of 2 drug regimens in children: chloral hydrate (CH), meperidine (M), and hydroxyzine (H) (regimen A) versus midazolam (MZ), M, and H (regimen B). Patients between 24 and 54 months of age were examined by crossover study design. Behavior was analyzed objectively by the North Carolina Behavior Rating System and subjectively through an operator and monitor success scale. Physiological data were recorded every 5 minutes and at critical points throughout the appointment. Sixteen patients completed this study. No significant differences in behavior were noted by the North Carolina Behavior Rating System or the operator and monitor success scale. A quiet or annoyed behavior was observed 93% and 90% of the time for regimen A and regimen B, respectively. Using the operator and monitor success scale, 63% of regimen A and 56% of regimen B sedations were successful. No statistically significant differences were noted in any of the physiological parameters between the 2 regimens. Ten episodes of hemoglobin desaturation were detected with regimen A sedations. There were no differences between the sedative drug regimens CH/M/H and MZ/M/H for behavioral outcomes or physiological parameters.

Abstract

The role of temperature in the action of local anesthetics was studied in 20 healthy young volunteers with plain 3% mepivacaine injected periapically twice in their maxillary first premolar, the first time with the solution at a temperature of 20°C and the second time at 4°C. The pulpal response was measured with a pulp tester every minute. The onset of pulp anesthesia was found to be of no statistical difference between 20°C and 4°C. On the other hand, mepivacaine at a temperature of 4°C was found to have a statistically significant longer duration of action. Our conclusion is that the drop in temperature of mepivacaine from 20°C to 4°C provides a longer duration of pulpal anesthesia.

Address correspondence to Shinji Kurata, Department of Clinical Physiology, Graduate School of Biomedical Science, Nagasaki University, 1-7-1, Sakamoto, Nagasaki 852-8588, Japan.

Effect of Subhypnotic Dosage of Propofol on Formalin-evoked Spinal Nitric Oxide Release and Behavioral Responses in Rats Shinji Kurata, Takao Ayuse, Kumiko Oi (Chief: Prof. Kumiko Oi)J JPN DENT SOC ANESTHESIOL2006;34:155-163.

It has been reported that hyperalgesia is caused by central sensitization in the spinal dorsal horn neuron due to activation of nociceptive transmission of nitric oxide (NO). Recently, it has been suggested that propofol, the most frequently used intravenous

Changing of the Guard in Pittsburgh: C. Richard Bennett, DDS, PhD, Retires

Attenuation of C-Reactive Protein Increases After Exodontia by Tramadol and Ibuprofen

Abstract

A Prospective Study of 2 Sedation Regimens in Children: Chloral Hydrate, Meperidine, and Hydroxyzine Versus Midazolam, Meperidine, and Hydroxyzine

Abstract

The Role of Temperature in the Action of Mepivacaine

Abstract

Delirium During Intravenous Sedation With Midazolam Alone and With Propofol in Dental Treatment

Abstract

Essentials of Local Anesthetic Pharmacology

Abstract

JDSA Journal Abstracts

JDSA Journal Abstracts

Changing of the Guard in Pittsburgh: C. Richard Bennett, DDS, PhD, Retires

Attenuation of C-Reactive Protein Increases After Exodontia by Tramadol and Ibuprofen

A Prospective Study of 2 Sedation Regimens in Children: Chloral Hydrate, Meperidine, and Hydroxyzine Versus Midazolam, Meperidine, and Hydroxyzine

The Role of Temperature in the Action of Mepivacaine